Program

7:45 am Registration and Continental Breakfast

Lobby, Molecular Biology Research Building, 900 South Ashland Avenue

8:15 am Welcome and Introductory Remarks

Graham Moran, Program Chair

Herman Auditorium, Molecular Biology Research Building

8:30 am Lecture Session I: Enzyme Structure and Function

Dali Liu, Session Chair

8:30 am “Crystal Structures of Acetobacter aceti succinyl-coenzyme A: Acetate CoA-transferase (AarC) Reveal Specificity Determinants and Illustrate the Mechanism used by Class I CoA-transferases”

T. Joseph Kappock, Purdue University, West Lafayette, IN

9:00 am “Structure and Function in Family V of the Acetoacetate Decarboxylase-like Superfamily”

Nicholas R. Silvaggi, University of Wisconsin-Milwaukee, Milwaukee, WI

9:30 am “Structural and Functional Investigation of a 3’-monoepimerase Involved in the Biosynthesis of dTDP-chalcose”

Rachel L. Kubiak, University of Wisconsin-Madison, Madison, WI

10:00 am Coffee Break

10:20 am Lecture Session II: Co-factors

Keith Green, Session Chair

10:20 am “Folate Binding Site of Flavin-Dependent Thymidylate Synthase”

Eric M. Koehn, University of Iowa, Iowa City, IA

10:50 am “Mobile Electronic Structure of Oxygenated Reaction Intermediates from Homoprotocatechuate 2,3-Dioxygenase (2,3-HPCD) - A Tale of Two Mutants”

Michael M. Mbughuni, University of Minnesota, Minneapolis, MN

11:20 am “Nitric Oxide Modifies Histone Methylation Patterns by Inhibiting Jumonji C Domain Containing Demethylases”

Divya Vasudevan, University of Illinois at Chicago, Chicago IL

12:00 Lunch

1:30 pm Lecture Session III: Novel Approaches

Matthew Youngblut, Session Chair

1:30 pm “Disarming Infectious Microorganisms through Altered S-adenosylmethionine Metabolism”

Stephen P. Zano, University of Toledo, OH

2:00 pm “Novel Histone Deacetylase 8 Ligands w/o Zn Chelating Group: Exploring an Upside-Down Pose”

Aditya Sudheer Vaidya, University of Illinois at Chicago, Chicago IL

2:30 pm “H/D Isotope-Sensitive Distributed Energy Barriers in the Aromatization Reaction of Human Aromatase”

Abhinav Luthra, University of Illinois at Urbana-Champaign, Urbana IL

3:00 pm “A bottom-up Approach to the Study of Binuclear Electron Transfer Center (CuA) in Biology”

Saumen Chakraborty, University of Illinois at Urbana-Champaign, Urbana IL

3:30 pm Closing Remarks

Bernie Santarsiero, Local Arrangements Chair

3:40 pm Poster Session

6:00 pm End